Q71-77: Transfusion Status from Diagnosis to the Start of the Preparative Regimen / Infusion

Question 71: Were red blood cell transfusions received?

Red blood cell (RBC) transfusions are often given as supportive care to re-establish baseline hemoglobin counts for recipients diagnosed with aplastic anemia. If the recipient received any RBC transfusions between diagnosis and the start of the preparative regimen / infusion, select Yes. If the recipient did not receive any RBC transfusions or no information is available to determine if the recipient received RBC transfusions, report No and go to question 75.

Question 72: Specify number of red blood cell transfusion exposures (best estimate) (during an exposure, a patient may receive > 1 unit; however, this is counted as a single event)

Indicate the total number of red blood cell transfusion exposures the recipient received after diagnosis and before the start of the preparative regimen. Using your best judgment, estimate the total number of exposures based on progress notes and transfusion summaries since diagnosis. Seek physician clarification for the best estimate if the number of red blood cell transfusion exposures administered prior to the start of the preparative regimen / infusion is not documented.

Example: The progress notes from a referring physician that state the recipient received one red blood cell transfusion a month for one year and then two transfusions monthly for six months before arriving at the transplant center, report “18” as the number of red blood cell transfusion exposures.

Question 73: Were red blood cells irradiated?

Red blood cells may be irradiated prior to transfusion to prevent transfusion associated – GVHD (TA-GVHD). This information is typically found within the “blood blank” or “transfusion history” information.

Report Yes if any of the red blood cells administered between diagnosis and the start of the preparative regimen / infusion were irradiated.

If none of the red blood cells administered between diagnosis and the start of the preparative regimen were irradiated, report No.

If it is not known if the red blood cells were irradiated, seek clarification from the blood bank. If it cannot be determined if irradiated red blood cells were administered prior to the start of the preparative regimen, report Unknown.

Question 74: Were red blood cells leukodepleted?

Red blood cells may be leukodepleted to prevent post-transfusion complications by reducing the number of WBCs transfused. This information is typically found within the “blood blank” or “transfusion history” information.

Report Yes if any of the red blood cells administered between diagnosis and the start of the preparative regimen / infusion were leukodepleted.

If none of the red blood cells administered between diagnosis and the start of the preparative regimen were leukodepleted, report No.

If it is not known if the red blood cells were leukodepleted, seek clarification from the blood bank. If it cannot be determined if leukodepleted red blood cells were administered prior to the start of the preparative regimen, report Unknown.

Question 75: Were platelet transfusions received?

Like RBC transfusions, platelet transfusions are given as supportive care to re-establish baseline platelet counts for recipients diagnosed with aplastic anemia. If the recipient received any platelet transfusions between diagnosis and the start of the preparative regimen / infusion, select Yes. If the recipient did not receive any platelet transfusions or no information is available to determine if the recipient received platelet transfusions, report No and continue with question 78.

Question 76: Specify number of platelet transfusions given (best estimate)

Indicate the total number of platelet transfusion exposures the recipient received after diagnosis and before the start of the preparative regimen. Using your best judgment, estimate the total number of transfusion exposures based on progress notes and transfusion summaries since diagnosis. Seek physician clarification for the best estimate if the number of platelet transfusion exposures administered prior to the start of the preparative regimen / infusion is not documented.

Example: The progress notes from a referring physician that state the recipient received one platelet transfusion a month for one year and then two transfusions monthly for six months before arriving at the transplant center, report “18” as the number of platelet transfusion exposures.

Question 77: Were the platelet transfusions HLA matched?

HLA matched platelets are given to recipients with thrombocytopenia who have refractory immune thrombocytopenia. This information is typically found within the blood bank information.

Report Yes if any of the platelets administered between diagnosis and the start of the preparative regimen / infusion were HLA matched.

If none of the platelets administered between diagnosis and the start of the preparative regimen were HLA matched, report No.

If it is not known if the platelets were HLA matched, seek clarification from the blood bank. If it cannot be determined if HLA matched platelets were administered prior to the start of the preparative regimen, report Unknown.

Section Updates:

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