JMML Response Criteria

!JMML Disease Status Response Options
Currently, the pre-infusion disease status options on the Disease Classification (2402) Form do not match the JMML response options listed below. When reporting the pre-infusion disease status on the Disease Classification (2402) Form, review the JMML Disease Status Response Options (Table 1) below to determine which option should be selected.

Complete Remission (CR)

Normalization of WBC and resolution of organomegaly.

Partial Remission (PR)

≥ 50% reduction of WBC from maximum pre-treatment value and/or ≥ 50% reduction of organomegaly from pre-treatment maximum

Marginal Response (MR)

25-50% reduction of WBC from maximum pre-treatment value and 25-50% reduction of organomegaly from pre-treatment maximum
or
≥ 50% reduction of WBC from maximum pre-treatment value and no change in organomegaly
or
≥ 50% reduction of organomegaly from pre-treatment maximum and no change in WBC

Stable Disease (SD)

≤ 25% reduction of WBC from maximum pre-treatment value and/or ≤ 25% reduction of organomegaly from pre-treatment maximum

Progressive Disease (PD)

Increase in WBC and/or organomegaly

Relapse

Reappearance of disease characteristics such as leukocytosis, absolute monocytosis, and organomegaly after complete remission (CR)

Not assessed

No assessment of leukocytosis or organomegaly was done at any time after therapy. If the patient was not treated, no assessment of leukocytosis or organomegaly was done at any time after diagnosis.

Table 1. JMML Disease Status Response Options

JMML Response Criteria	2402 Disease Status Response Options
Complete remission	Complete remission
Partial remission	Hematologic improvement (Specify cell lines examined to determine HI status is disabled for JMML)
Marginal response	Hematologic improvement (Specify cell lines examined to determine HI status is disabled for JMML)
Stable disease	No response / stable disease
Progressive disease	Progression from hematologic improvement
Relapse	Relapse from complete remission
Not assessed	Not applicable, select CR, HI, NR / SD, Progression from hematologic improvement, or Relapse from complete remission

Manual Updates:
Sections of the Forms Instruction Manual are frequently updated. The most recent updates to the manual can be found below. For additional information, select the manual section and review the updated text.

If you need to reference the historical Manual Change History for this form, please click here or reference the retired manual section on the Retired Forms Manuals webpage.

Date	Manual Section	Add/Remove/Modify	Description
1/23/2026	JMML Response Criteria	Add	JMML Disease Status Response Options red warning box and Table 1. JMML Disease Status Response Options table added

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