Q48-58: Disease Assessment Between Diagnosis and the Start of the Preparative Regimen

Question 48: Were central nervous system (CNS) abnormalities found on computed topography (CT or CAT) or magnetic resonance imaging (MRI) scans?

Indicate if radiology (CT, CAT, and/or MRI) performed on the recipient between diagnosis and the start of the preparative regimen detected any abnormalities in the CNS (brain and spinal cord). CNS abnormalities may include lesions, leptomeningeal enhancements, or edema.

If CNS abnormalities were detected on the radiological examination, select “yes” and continue with question 49. If no CNS abnormalities were detected on the radiological examination, select “no” and continue with question 50. If it is unknown if abnormalities were present or if no CT/CAT/MRIs were performed, select “unknown” and continue with question 50.

Question 49: Date scan was performed:

Enter the date the radiological assessment was performed.

If the exact date is not known, use the process for reporting partial or unknown dates as described in General Instructions, Guidelines for Completing Forms.

Question 50: Were there any clinical neurologic abnormalities present?

Based on a clinical neurologic assessment, indicate if there were any clinical neurological abnormalities between diagnosis and the start of the preparative regimen. Neurologic abnormalities include abnormal gait, cranial nerve palsies, developmental delay, motor weakness, seizures, and sensory deficits. If clinical neurological abnormalities were present between diagnosis and the start of the preparative regimen, select “yes” and continue with question 51. If no clinical neurologic abnormalities were present, select “no” and continue with question 59. If it is not known if clinical abnormalities were present, select “unknown.”

Questions 51-58: Specify neurologic abnormalities:

Indicate the clinical neurological abnormalities present between diagnosis and prior to the start of the preparative regimen. Select “yes” or “no” for each question and ensure that no question is left blank. If a neurological abnormality is not listed but was present, select “yes” for question 57 (“other neurologic abnormality”) and specify the abnormality using question 58.

Section Updates:

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