Veno-occlusvie disease (VOD) / Sinusoidal obstruction syndrome (SOS) occurs following injury to the hepatic venous endothelium, resulting in hepatic venous outflow obstruction due to occlusion of the hepatic venules and sinusoids. This typically results in a distinctive triad of clinical signs including hepatomegaly with right upper quadrant tenderness, third space fluid retention (e.g., ascites), and jaundice with a cholestatic picture. For more information on VOD / SOS including diagnostic criteria, refer to the VOD / SOS section of the Forms Instructions Manual.
Questions 37 – 38: Did veno-occlusive disease (VOD) / sinusoidal obstruction syndrome (SOS) develop?
Indicate whether VOD / SOS was diagnosed during the reporting period. If Yes, report the date of diagnosis. If VOD / SOS persisted from the prior reporting period, report No.
If VOD/SOS was reported on the Post-TED (2450) Form, the Veno-Occlusive Disease (VOD) / Sinusoidal Obstruction Syndrome (SOS) (2553) Form must also be completed.
For more information regarding reporting partial or unknown dates, see General Instructions, General Guidelines for Completing Forms.
Section Updates:
| Question Number | Date of Change | Add/Remove/Modify | Description | Reasoning (If applicable) |
|---|---|---|---|---|
| Q37 | 1/23/2026 | Add | Combined Follow Up and VOD / SOS blue box added: Combined Follow-Up and VOD / SOS: In scenarios where a cellular therapy was given after an HCT and this form is now being completed based on the subsequent cellular therapy date, these questions still apply and should be answered. | Added for clarification |
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