Q69 – 81: Assessment of Nodal and Organ Involvement at Diagnosis

*Diagnostic Assessments
All values reported must reflect testing / evaluations performed prior to any treatment for the histology at diagnosis as specified above. If testing / evaluation was not done near the time of diagnosis (within approximately 30 days) and prior to the initiation of treatment, report Unknown.

Questions 69 – 70: Was a PET (or PET/CT) scan performed?

Positron Emission Tomography (PET) is a type of nuclear medicine imaging in which a patient receives a small amount of radioactively labeled sugar. Because cancer cells absorb sugar more avidly than other cells of the body, the radioactively labeled sugar accumulates in these areas and reveals tumors as bright spots. A PET/CT combines the results of the PET scan along with the results of a CT (computed tomography) scan.

Specify if a PET (or PET/CT) scan was performed at diagnosis. If Yes, indicate whether the scan was positive for lymphoma. Consult a physician if the report is unclear.

If a PET or (PET/CT) scan was not performed at diagnosis or is unknown, report No.

Question 71: Did the recipient have known nodal involvement?

Nodal involvement may be assessed by a physician palpating lymph nodes, pathology from a lymph node biopsy, or radiological assessment (e.g., PET or CT imaging).

Indicate if nodal involvement was detected at diagnosis. If nodal involvement was not detected, or it is unknown if detected, report No.

Question 72: Specify total number of nodal regions involved (excluding follicular)

Lymph node regions or groups occur above and below the diaphragm. Nodal regions include cervical (neck), axillary (underarm), mediastinal (thoracic), mesenteric (abdominal), para-aortic (pelvic), inguinal (groin), epitrochlear (inside of arm just above elbow), and popliteal (back of knee). Indicate the total number of nodal regions with evidence of lymphoma involvement. Refer to Graphic 1. Nodal Areas below for identification of nodal areas and specific nodes within each area.

Specify the total number of nodal regions involved at diagnosis.

Question 73: Specify total number of nodal regions involved (follicular only)

Lymph node regions or groups occur above and below the diaphragm. Nodal regions include cervical (neck), axillary (underarm), mediastinal (thoracic), mesenteric (abdominal), para-aortic (pelvic), inguinal (groin), epitrochlear (inside of arm just above elbow), and popliteal (back of knee). Indicate the total number of nodal regions with evidence of lymphoma involvement. Refer to Graphic 1. Nodal Areas below for identification of nodal areas and specific nodes within each area.

Specify the total number of nodal regions involved at diagnosis.

Graphic 1. Nodal Areas¹

¹ “Lymphadenopathy.” Web log post. Horses and Zebras. Morning Report at Toronto General Hospital, 20 July 2010. Accessed on 9/22/2013 at http://morningreporttgh.blogspot.com/2010/07/lymphadenopathy.html.

Question 74: Specify the size of the largest nodal mass

Report the size of the largest known nodal mass at diagnosis (as measured in centimeters). If the mass is given in three dimensions (example, 3 cm x 5 cm x 4 cm), report the longest two dimensions.

Question 75: Was there any known extranodal or splenic involvement? (at diagnosis, prior to any transformation)

Extranodal refers to the presentation of lymphoma outside of the lymph nodes. Common areas of extranodal involvement may include bone, gastrointestinal tract, and skin.

Splenic involvement in lymphoma is also common. It is usually evidenced by enlargement of the spleen (splenomegaly). Splenic or other extranodal involvement is most often detected by imaging techniques or pathological findings.

Specify if extranodal or splenic involvement was identified at diagnosis.

Questions 76 – 77: Specify site(s) of involvement (check all that apply)

Specify all sites with known lymphomatous involvement at diagnosis. Clarifications on some of the available option values are found below:

• Adrenal: The adrenals gland are small glands that sit on the top of each kidney and product hormones including sex hormones and cortisol. Select this option if there was lymphomatous involvement of or derived from the adrenal glands or their secretions.
• Cerebrospinal fluid (CSF): A clear, colorless body fluid found in the brain and spinal cord that is produced by specialized ependymal cells.
• Epidural space: The epidural space is an anatomic space that is the outermost part of the spinal canal. The epidural space contains lymphatics, spinal nerve roots, loose fatty tissue, small arteries, and a network of internal vertebral venous plexuses.
• Gastrointestinal (GI) tract: Any of the organs that food and liquids travel through when they are swallowed, digested, absorbed, and leave the body as feces. These organs include the mouth, pharynx, esophagus, stomach, small intestine, large intestine, rectum, and anus.
• Pericardium: Of or pertaining to the membrane enclosing the heart that consists of an outer fibrous later and an inner double layer of serous membrane.
• Pleura:The delicate serous membrane that lines each half of the thorax of mammals and is folded back over the surface of the lung of the same side. The function of the pleura is to allow optimal expansion and contraction of the lungs during breathing.
• Skin: Of or pertaining to the outer or surrounding layer of the skin (epidermis).
• Spleen: Of or pertaining to the abdominal organ involved in the product and removal of blood cells.
  

If an involved site was documented but is not listed as an option, check Other site and report all other sites of lymphomatous involvement at diagnosis.

Question 78: Stage of organ involvement

Using Table 1. Lymphoma Staging below, report the organ involvement at diagnosis.

If staging at diagnosis is not available or not known, select Unknown.

Table 1. Lymphoma Staging

Stage	Description
Stage I	Involvement of a single lymph node region or of a single extralymphatic organ or site
Stage II	Involvement of two or more lymph node regions on same side of diaphragm, or localized involvement of an extralymphatic organ or site, and one or more lymph node regions on same side of diaphragm
Stage III	Involvement of lymph node regions on both sides of diaphragm, which may also be accompanied by localized involvement of extralymphatic organ or site, the spleen, or both
Stage IV	Diffuse or disseminated involvement of one or more extralymphatic organs in tissues with or without associated lymph node enlargement/involvement

Graphic 2. Lymphoma Staging²

² “Staging Lymphomas.” Patients Against Lymphoma. 05 May 2013. Accessed on 9/22/2013 at http://www.lymphomation.org/stage.htm.

Graphic 3. Staging Classification³

³ “Ann Arbor” Staging Classification,” “Lymphoma: Clinical- Hodgkin’s Lymphoma.” Pathology Tool. University of Virginia Medical School. 02 May 2012. Accessed 9/22/2013 at http://www.med-ed.virginia.edu/courses/path/innes/wcd/hodgclinic.cfm.

Question 79: Were systemic symptoms (B symptoms) present? (unexplained fever < 38° C; or night sweats; unexplained weight loss > 10% body weight in six months before diagnosis)

Systemic symptoms, also known as “B” symptoms, are defined as follows:

• Unexplained fever > 38° C (100.4°F)
• Night sweats
• Unexplained weight loss of > 10% of body weight over 6 months
  

Evidence of systemic symptoms is significant because it may indicate the presence of disease in parts of the body not identified using standard testing methods. The presence or absence of systemic symptoms may be indicated in the staging (e.g., II-B or II-A).

Indicate if there was evidence of systemic symptoms at diagnosis.

If documentation is not clear or is not available to determine if systemic symptoms were present at diagnosis or prior to first therapy, select Unknown.

Questions 80 – 81 : ECOG score (at diagnosis)

Recipient performance status is a critical data field that has been determined to be essential for all outcome-based studies. If a performance score is not documented in the source documentation (e.g., inpatient progress note, physician’s clinic notes), data management professionals should not assign a performance score based on analysis of available documents. Rather, a physician should provide documentation of the performance score. Documentation from an RN who has been trained and authorized to determine performance scores may also be used.

If the performance score has been documented using Karnofsky or Lansky scales, refer to” Appendix L: Karnofsky / Lansky Performance Status”:https://www.manula.com/manuals/cibmtr/fim/1/en/topic/appendix-l-karnofsky-lansky-performance-status for assistance converting the score to the ECOG scale.

Report whether the recipient’s ECOG score at diagnosis is known and report the score, if applicable.

Section Updates:

Question Number	Date of Change	Add/Remove/Modify	Description	Reasoning (If applicable)
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