This section of the HCT Infusion (2006) form captures pre-collection therapy information regarding the donor’s mobilization or priming and is not completed for cord blood units or products from NMDP donors.
Question 1: Did the donor receive growth and mobilizing factors, prior to any stem cell harvest, to enhance the product collection for this HCT? (Allogeneic donors only)
Stem cells do not typically circulate in the blood stream. Therefore, in order to increase the quantity of cells for collection, an agent is frequently given to the allogeneic donor. The purpose of the agent is to move the stem cells from the bone marrow into the peripheral blood where the cells can be collected by apheresis. This practice is often referred to as mobilization or priming. Occasionally, a donor may be primed using a growth factor prior to collection of bone marrow.
Indicate if the allogeneic donor received therapy (such as growth factors, mobilizing agents, etc.) to enhance the product collection.
If the allogeneic donor did not receive therapy to enhance the stem cell product or it is not known, report No.
This question is only enabled for PBSC and bone marrow products from non-NMDP donors.
Questions 2 – 3: Specify growth and mobilizing factor(s) (check all that apply)
Select the growth and mobilizing factors given to enhance the product collection. Check all that apply.
If a growth or mobilizing factor was given is not included in the above list, select Other growth or mobilizing factor(s) and specify the generic name for the growth or mobilizing factor.
Examples of growth and mobilizing factors include, but are not limited to, the following:
- G-CSF: Granulocyte-colony stimulating factor, TBO-filgrastim, filgrastim, Granix, Neupogen, Zarixo, Nivestim, and biosimilars
- Pegylated G-CSF: Pegfilgrastim, Neulasta
- Motixafortide: Aphexda
- Plerixafor: Mozobil and biosimilars
- Other growth or mobilizing factors: Epidermal growth factor (EGF), erythropoietin (EPO), fibroblast growth factor (FGF), granulocyte-macrophage colony stimulating factor (GM-CSF), growth differentiation factor-9 (GDF9), hepatocyte growth factor (HGF), insulin-like growth factor (IGF), platelet-derived growth factor (PDGF), thrombopoietin (TPO), transforming growth factor alpha –(TGF-α), transforming growth factor beta (TGF-β)
Section Updates:
| Question Number | Date of Change | Add/Remove/Modify | Description | Reasoning (If applicable) |
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