Q11 – 14: Megakaryopoiesis / Platelet Recovery

!Megakaryopoiesis / Platelet Recovery
The megakaryopoiesis / platelet recovery section can only be completed on the 100 day, 6 month, 1 year, and 2 year follow-up forms. These questions will be skipped for all subsequent reporting periods.

*Combined Follow-Up
In scenarios where a cellular therapy was given after an HCT and this form is now being completed based on the subsequent cellular therapy date, these questions do not apply and are disabled.

*ANC / Platelet Recovery Reporting Overview
Refer to the ANC / Platelet Recovery reporting overview for information on reporting ANC recovery.

*Not Applicable and Previously Reported
When Not applicable is reported for Day 100 reporting period, select Previously reported for all future reporting periods.

Question 11: Was an initial platelet count ≥ 20 × 10⁹/L achieved?

Indicate if there was evidence of initial platelet recovery following this HCT.

• Yes: Platelet count ≥ 20 × 10⁹ / L was achieved and sustained for three consecutive laboratory values, obtained on different days without platelet transfusions administered in the previous seven days
• No: Platelet count was not ≥ 20 × 10⁹ / L or if platelet transfusions were administered in the previous seven days.
• Not applicable: The platelets never dropped below 20 × 10⁹/L at any time post-infusion and a platelet transfusion was never required.
  • If the recipient’s platelet count drops below 20 × 10⁹/L and/or the recipient received a platelet transfusion even once, do not use this option. This option is only applicable in the Day 100 reporting period.
• Previously reported: This is the six-month or annual follow-up, and initial platelet recovery has already been reported on a previous form.

*Reporting Estimated Dates
If a recipient is not seen within a month after their last platelet transfusion, an estimated date may be reported. In this case, the date seven days after the last platelet transfusion may be reported (see example below). However, if the recipient is seen within a month of the last platelet transfusion, an estimated date should not be reported.

Question 12: Date platelets ≥ 20 × 10⁹/L

Enter the first date of three consecutive laboratory values obtained on different days where the platelet count was ≥ 20 × 10⁹/L. Ensure that no platelet transfusions were administered for seven days immediately preceding this date. Include day seven, as shown in the Reporting Platelet Recovery example in the” ANC / Platelet Recovery”:https://www.manula.com/manuals/cibmtr/fim/1/en/topic/anc-platelet-recovery reporting overview, when determining the recovery date.

If three laboratory values were not obtained on consecutive days, but a sequential rise of ≥ 20 × 10⁹/L is demonstrated, follow the examples below when determining an estimated date.

Reporting Scenarios:

• Example 1: The recipient is being seen in the outpatient clinic and receives a platelet transfusion on January 1. The platelet count is 22 × 10⁹/L on January 2, 24 × 10⁹/L on January 3, and 28 × 10⁹/L on January 4. The recipient does not come into the clinic for evaluation until one month later. The recipient has not received any more platelet transfusions and the platelet count is well above 20 × 10⁹/L. Report January 8 (day seven post-platelet transfusion) for the date of platelet recovery.
• Example 2: The recipient is being seen in the outpatient clinic and receives a platelet transfusion on January 1. The platelet count is ≥ 20 × 10⁹/L on January 2, January 3, and January 4. The recipient is then discharged back to their primary care physician. The transplant center receives a follow-up note from the primary care physician that states “recipient recovered their platelets in January of 2011.” Report an estimated date of recovery using the guidelines available in General Instructions, General Guidelines for Completing Forms.
  

Question 13: Was an initial platelet count ≥ 50 × 10⁹/L achieved?

Indicate whether a platelet count of ≥ 50 × 10⁹/L was achieved following this HCT.

• Yes: Platelet count ≥ 50 × 10⁹ / L was achieved and sustained for three consecutive laboratory values, obtained on different days without platelet transfusions administered in the previous seven days.
• No: Platelet count was not ≥ 50 × 10⁹ / L or if platelet transfusions were administered in the previous seven days.
• Not applicable: The platelets never dropped below 50 × 10⁹/L at any time post-infusion and a platelet transfusion was never required.
  • If the platelet count drops below 50 × 10⁹/L and / or the recipient received a platelet transfusion even once, do not use this option. This option is only applicable in the Day 100 reporting period.
• Previously reported: This is the six-month or annual follow-up, and a platelet count of ≥ 50 × 10⁹/L was achieved and reported previously

Question 14: Date platelets ≥ 50 × 10⁹/L

Enter the first date of three consecutive laboratory values obtained on different days where the platelet count was ≥ 50 × 10⁹/L. Ensure that no platelet transfusions were administered for seven days immediately preceding this date. Include day seven, as shown in the Reporting Platelet Recovery example in the” ANC / Platelet Recovery”:https://www.manula.com/manuals/cibmtr/fim/1/en/topic/anc-platelet-recovery reporting overview, when determining the recovery date.

If three laboratory values were not obtained on consecutive days, but a sequential rise of ≥ 50 × 10⁹/L is demonstrated, follow the examples included in the instructions above.

For more information regarding reporting partial or unknown dates, see General Instructions, General Guidelines for Completing Forms.

Section Updates:

Question Number	Date of Change	Add/Remove/Modify	Description	Reasoning (If applicable)
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