Q47-49: Avascular Necrosis

Questions 47 – 49: New onset of avascular necrosis:

Avascular necrosis is the death of bone tissue due to a lack of adequate blood supply. It is sometimes called osteonecrosis and can lead to minute fractures in the bone followed by eventual collapse. Avascular necrosis can spread from joint to joint.

Indicate if there was a new onset of avascular necrosis in the current reporting period.

Report Yes in the following scenarios:

• A new onset of avascular necrosis occurred since the date of last report
• There is a prior diagnosis of avascular necrosis of a joint and a new joint(s) was diagnosed with avascular necrosis since the date of last report (see example below)
  

Report No in the following scenarios:

• If a new onset of avascular necrosis did not occur in the current reporting period
• Avascular necrosis of a specific joint occurred in a prior reporting period and persisted into the current reporting period

If no information is available to determine if a new onset of avascular necrosis was experienced since the date of last report, Unknown.

See examples of reporting scenarios listed below.

Question 48: Specify joint(s) affected (check all that apply)

Specify the joint(s) affected by the new onset of avascular necrosis; check all that apply. If there was avascular necrosis of a joint not listed, report Other and specify the joint.

Avascular Necrosis Reporting Scenarios:
p(. A. A recipient is diagnosed with avascular necrosis of the hip pre-transplant. Following infusion, the recipient develops avascular necrosis of the left shoulder.

100 Day Post-Infusion Data Form:
Question 47: Report “Yes” to capture the new development of avascular necrosis of the left shoulder.
Question 48: Select “Shoulder” and continue with the form. “Hip” will not be selected as this was diagnosed pre-transplant.

B. A recipient with diagnosed with avascular necrosis of the right knee and resolves in the Day 100 reporting period. In the six-month reporting period, the recipient does not experience avascular necrosis but in the one-year reporting period, the recipient is diagnosed with avascular necrosis of both the right and left knees.

Day 100 Post-Infusion Data Form:
Question 47: Report “Yes” to indicate the diagnosis of avascular necrosis of the right knee.
Question 48: Select “Knee.”

Six Month Post-Infusion Data Form:
Question 47: Report “No” as there was not a new onset of avascular necrosis during the reporting period.

One Year Post-Infusion Data Form:
Question 47: Report “Yes” to capture the onset of avascular necrosis of the left knee.
Question 48: Select “Knee” again.

Section Updates:

Question Number	Date of Change	Add/Remove/Modify	Description	Reasoning (If applicable)
.	.	.	.	.

Copyright © 2004-2024 The Medical College of Wisconsin, Inc. and NMDP. All Rights Reserved.
CIBMTR® (Center for International Blood and Marrow Transplant Research) is a research collaboration between the Medical College of Wisconsin and NMDP.