5. Sample Preparation

Depending on the sample amount, either genomic DNA or isolated immune cells (i.e., DirectCell Protocol) can be used as input for the DriverMap AIR TCR/BCR DNA Assay.

• For bulk tissue, blood, or cell samples with more than ~50,000 cells, follow the recommendations of the General DNA Preparation Protocol
  

• For biological samples with a small number of cells—less than ~50,000 cells (e.g., sorted immune cells) or blood and tissue micro samples—we recommend using the immune cells directly as input. Follow the guidelines in the DirectCell Protocol below (Section 5.2).